For this step a human model with low number of polygons and a clip is necessary.
We will execute an instance between particles and four copies of geometry; different clip must be applied at each geometry copies to obtain 15 people that runs in various way. Now import the geometries and apply the 4 different clip; for every clip set up the attribute Post Cycle to a sufficient value for the entire simulation.

Now execute Particles/Instancer(Replacement) between particles and the four precedent objects.
To assing different animation clip to every particles, inside the Instancer menu set up opportunely the ObjectIndex attribute.

We have finished the simulation, the next image shows the complete scene.
With the Crowd Maker menu you can control all the attributes of the script, try many values to find the best result. To obtain a uniform movement of the crowd you must set a high value for Alignment.

On the next image we can see some of the animation frame.

In this example we have created a scene with only 15 particles, the script works with a maximum of 1000.
You can download examples and some scripts here, all the software was provided in a rar/zip archive on the Script section.